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Acetamide,N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-? price Acetamide,N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-? CAS 87-11-6 Acetamide,N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-? supplier in China
superior quality
THIOLUTIN Chemical Properties |
storage temp. | −20°C |
solubility | DMSO: 5 mg/mL |
Safety Information |
Hazard Codes | T+,T |
Risk Statements | 28 |
Safety Statements | 45 |
RIDADR | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | JP1355000 |
THIOLUTIN Usage And Synthesis |
Chemical Properties | Yellow solid |
Usage | Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumour activity. Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, and also inhibits mannan and glucan formation in fungi. Thiolutin suppresses tumour cell-induced angiogenesis in vivo. |
Usage | Thiolutin is an antibiotic isolated from several strains of Streptomyces albus. Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases. |
Biological Activity | Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC 50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis. |
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