CasNo.362-07-2,Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-,(362-07-2) Suppliers

10 Kilogram	Negotiable

Min.Order :10 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,Other

Keywords

Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? price Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? CA 362-07-2 Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-? supplier in China

Quick Details

Appearance:off-white soild
Application:Used for Pesticide intermediates A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of
PackAge:1kg/bag, 1kg/drum or 25kg/drum or as per your request.
ProductionCapacity:1|Metric Ton|Month
Storage:Stored in cool, dry and ventilation place; Away from fire and heat
Transportation:as per your request

Superiority:

superior quality

Details:

2-METHOXYESTRADIOL Chemical Properties

mp	188-190°C
storage temp.	−20°C
solubility	DMSO: 10 mg/mL
form	crystalline
color	light yellow
CAS DataBase Reference	362-07-2(CAS DataBase Reference)

Safety Information

Hazard Codes	T,Xi
Risk Statements	23/24/25-36/37/38-48-61-60-46-45
Safety Statements	22-26-36/37/39-45-53-36
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	KG7537500

MSDS Information

Provider	Language
SigmaAldrich	English

2-METHOXYESTRADIOL Usage And Synthesis

Chemical Properties	Off-White Solid
Usage	A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Usage	A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Usage	2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Usage	2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Usage	2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Biological Activity	Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.