DHPG Cytovene Cymevene ganciclovir factory in China high quality

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 280.0000 -296.0000

1 Kilogram

FOB Price:USD 280.0000 -296.0000

Min.Order :1 Kilogram
Purity: 99
Payment Terms : L/C,T/T

Keywords

API intermediate gancyclovir

Quick Details

Appearance:White or almost white crystalline powder
Application:82410-32-0
PackAge:
ProductionCapacity:|Metric Ton|Day
Storage:
Transportation:

Superiority:

Products:	Ganciclovir
Synonyms：	9-(1,3-Dihydroxy-2-propoxymethyl)guanine
CAS#:	82410-32-0
Molecular Formula:	C9H13N5O4
Molecular Weight:	255.23
Assay:	≥99.0%
EE:	≥99.0%
Appearance:	White or almost white crystalline powder
Structural：

1、White or almost white crystalline powder；

2、0.01-1kg/bag,5-25kg/tub；

3、1500kg/Month

Details:

Ganciclovir is a synthetic analogue of 2′-deoxy-guanosine. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells.

Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route.

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