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sofosbuvir 1190307-88-0 API
Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3 and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone. It is also used in HCV patients with an HIV coinfection.[8] The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.[14][15]
In early 2014, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) jointly published a recommendation for the management of hepatitis C. In this recommendation, sofosbuvir and ribavirin, with or without pegylated interferon, are part of all first-line treatments for HCV genotypes 1 to 6, and are also part of some second-line treatments.
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