Isatin 91-56-5 98%

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Isatin Isatin, is also known as indenedione, indole quinone. Its chemical name is indol(o)-2,3-dione,it is orange-red monoclinic prism crystal at room temperature. Bitter. The molecular weight is147.13. Melting point 203.5 ℃ (Part sublimation). Dissolved in water, hot ethanol, benzene, acetone, ether-soluble. Soluble in boiling alcohol, soluble in ether and boiling water  and it is reddish brown , soluble in caustic and solution is purple, it changes to yellow after placement. Its alcohol solution   has a very unpleasant odor. Weakly alkaline, it can salify with a perchlorate.
Above information of is edited by Andy from ChemicalBook (2016-11-19).
Chemical Properties Orange-red monoclinic prism crystals. Melting point 203.5 ℃ (Part sublimation). Soluble in hot ethanol, ethyl ether-soluble, soluble in hot water, benzene, acetone, dissolved in alkali metal hydroxide oxide. The solution is purple, it turns yellow after placement, alkaline activity is extremely weak. Bitter.
Uses (1) The product is used as medicine and dye intermediates ,and it is used for the production of drug  quinophan, dye disperse Yellow E-3G ; in chemical analysis,it is used as reagents for the determination of copper ions, mercaptans, thiophene,  indoxyl-beta-glucoside.
(2) Isatin as a reference material for the preparation of indigo and Maya blue; for the preparation of phthalazinone derivatives, spirooxindole derivatives, the expression of P-glycoprotein for multi-drug resistant cells; The ketone is fused to form indole-2-one as a tubercular mycobacterial protein tyrosine phosphatase B, a potent selective inhibitor, as a powerful antimicrobial and antifungal triazole-isatine complex, And the Knoevenagel enrichment reaction; the isatin is activated by the direct sp2 / sp3C-H bond, and undergoes a reaction with the cyclopentadienyl- Pd (II) catalyzes the CH addition reaction to form 3-substituted-3-hydroxy 2-oxindole.
production method Condensation of chloral and aniline  can generate  oximide-acetanilide, and then by cyclization, hydrolysis , isatin is obtained.
Chemical Properties orange-red powder or crystals
Isatin Preparation Products And Raw materials
Raw materials Indigo-->2,2,2-Trichloroacetamide
Preparation Products Indole-->Indazole-3-carboxylic acid-->1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE-->Solvent Yellow 114-->1-Methylindazole-3-carboxylic acid-->Lonidamine-->3-(HYDROXYMETHYL)INDAZOLE-->6-BROMO-2-METHYL-QUINOLINE-4-CARBOXYLIC ACID-->CINCHOPHEN-->Indirubin-->3-ACETYL-2-METHYL-QUINOLINE-4-CARBOXYLIC ACID-->1-(2,6-Dichlorophenyl)indole-2,3-dione-->3,3-Bis(3-methyl-4-hydroxyphenyl)indoline-2-on-->1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER-->5-IODOISATIN-->1-Acetyl-1H-indole-2,3-dione-->3,3-BIS(P-HYDROXYPHENYL)OXINDOLE.