24280-93-1 Mycophenolic acid
4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide;6-(5-carboxy-3-methyl-2-pentenyl)-7-hydroxy-5-methoxy-4-methyl-phthalid;lilly-68618;melbex;micofenolicoacido;nsc-129185;(4E)-6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID;6-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-PHTHALANYL)-4-METHYL-4-HEXANOIC ACID
Mycophenolic acid Chemical Properties
mp 141°C
storage temp. 2-8°C
solubility methanol: 50 mg/mL, clear, colorless to faintly yellow
form powder
Merck 13,6352
CAS DataBase Reference 24280-93-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-61-40
Safety Statements 53-45-36/37
RIDADR 2811
WGK Germany 3
RTECS MP8050000
F 10
HazardClass 6.1(b)
PackingGroup III
Mycophenolic acid Usage And Synthesis
Chemical Properties White to Off-White Powder
Usage An antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
Usage immune suppressant, antineoplastic, antiviral
Usage antineoplastic, progestin
Usage Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation showed mycophenolic acid to display broad antitumour, antiviral, antifungal and antiprotozoan activities. Its potent immunosuppressant activity led to its commercial development to prevent kidney transplant rejection. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes.
Biological Activity Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo . Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.
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