Miltefosine

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 99% purity
Payment Terms : T/T,Other

Keywords

58066-85-6 Miltefosine 99% purity

Quick Details

Appearance:Crystalline Powder
Application:intermediate
PackAge:According to the need of packing
ProductionCapacity:100|Kilogram|Month
Storage:room temp
Transportation:air,sea,courier

Superiority:

Product Name:   Miltefosine
Synonyms:   2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-n,n,n-trimethyl-ethanaminiuhydrox;2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-n,n,n-trimethylethanaminiumhydroxid;cholinephosphate,hexadecylester,hydroxide,innersalt;d18506;Hexadecyl 2-(trimethylamino)ethyl phosphate;Miltex;13-18506;2-[[(Hexadecyloxy)hydroxyphasphinyl]oxy]-N，N，N-trimethylethanaminiminner salt
CAS:   58066-85-6
MF:   C21H46NO4P
MW:   407.57
EINECS:   622-572-6
Product Categories:   Inhibitors;Anti-cancer&immunity;Anti-virals;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Miscellaneous Natural Products;MILTEX;inhibitor
Mol File:   58066-85-6.mol

Details:

Melting point    232-234° (dec)
storage temp.    room temp
solubility    H2O: soluble10mg/mL, clear, colorless
form    Crystalline solid
InChIKey   PQLXHQMOHUQAKB-UHFFFAOYSA-N
CAS DataBase Reference   58066-85-6(CAS DataBase Reference)
Safety Information
Hazard Codes    Xn
Risk Statements    22-43
Safety Statements    36/37
RIDADR    UN 2811 6.1 / PGIII
WGK Germany    3
RTECS    KH2890000
Toxicity   LD50 in rats (mg/kg): 246 orally (Muschiol)

Description Miltefosin, representing the prototype of a new phospholipid structure, was introduced for the palliative treatment of skin metastases in patients with breast cancer. It is highly active against the human leukemia tumor cells xenograft in nude mice, leading to growth inhibition and regression of large established tumors. Its mode of antitumor activity is not mediated by the host immune system but by its pharmacological effects at the level of the cancer cell membrane, distinctly different from that of the classical cytostatic drugs which interact with cell proliferation at the level of DNA replication. Protein kinase C inhibition has been suggested as a possible mechanism.

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