research chemical similar to GLYX-13 for major depressive disorder (MDD)
77472-70-9 | phenylpiracetam | |
110958-19-5 | Fasoracetam | |
15180-02-6 | Amfonelic acid | |
68497-62-1 | Pramiracetam | |
116041-13-5 | Nebracetam | |
77191-36-7 | Nefiracetam | |
62613-82-5 | Oxiracetam | |
72432-10-1 | aniracetam | |
157115-85-0 | Noopept | |
59776-89-5 | Piracetam hydrazide | |
51352-87-5 | PRL-8-53 | |
22503-72-6 | IDRA-21 | |
1270138-40-3 | NSI-189 | |
272786-64-8 | Unifiram | |
314728-85-3 | Sunifiram | |
63547-13-7 | Adrafinil | |
33818-15-4 | Citicoline Sodium | |
987-78-0 | Citicoline | |
28319-77-9 | Alpha-GPC | |
120786-18-7 | Huperzine A | |
42971-09-5 | Vinpocetine | |
34271-54-0 | L-theanine | |
38183-03-8 | 7, 8 dihydroxy flavonoids | |
1689-64-1 | 9-fluorenol | |
127464-43-1 |
Mexidol |
NRX-1074 is a novel modulator of the NMDA receptor. It is a second-generation follow-on to Naurex’s lead compound, GLYX-13. NRX-1074 is similar to GLYX-13, but is orally active and significantly more potent. The drug is in Phase 2 clinical development for the treatment of major depressive disorder (MDD).
The objectives of the Phase 2 study now underway are to evaluate the safety and efficacy of a single dose of NRX-1074 administered to subjects with MDD. This Phase 2 study follows successful completion of a randomized, placebo-controlled Phase 1 study that assessed the safety of the compound in normal volunteers. In this study, NRX-1074 was well-tolerated, with no signs of the schizophrenia-like psychotomimetic effects associated with NMDA receptor antagonists, such as ketamine.
NRX-1074 has mechanistic activity similar to that of GLYX-13. In multiple nonclinical studies, NRX-1074 has shown rapid onset and long duration of antidepressant-like effects with good safety and no signs of CNS-related side effects.
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