CasNo.50-28-2,Estradiol 50-28-2 Largest in supply,(50-28-2) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T,Other

Keywords

50-28-2 Estradiol 99%

Quick Details

Appearance:white or milky white ordorless crystalline powde
Application:Estradiol is the major estrogen secreted by the premenopausal ovary.
PackAge:drums
ProductionCapacity:2|Metric Ton|Month
Storage:dry and cool
Transportation:air, courier and sea

Superiority:

Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol
CAS: 50-28-2
MF: C18H24O2
MW: 272.38
EINECS: 200-023-8
Product Categories: Steroids;Estrogen;Hormone;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;VIVELLE;Hormone Drugs;Inhibitors
Mol File: 50-28-2.mol
Estradiol Structure
Estradiol Chemical Properties
Melting point 178-179 °C(lit.)
refractive index 80.4 ° (C=1, Dioxane)
Fp 2℃
storage temp. 2-8°C
form powder
Water Solubility Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck 14,3703
BRN 1914275
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 50-28-2(CAS DataBase Reference)
NIST Chemistry Reference Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System Estra-1,3,5(10)- triene-3,17-diol (17.beta.)-(50-28-2)
Safety Information
Hazard Codes T,Xn,F
Risk Statements 60-61-45-63-64-40-36-20/21/22-11
Safety Statements 53-22-36/37/39-45-36/37-26-16
RIDADR 2811
WGK Germany 3
RTECS KG2975000
F 8-10
HazardClass 6.1
PackingGroup III
Hazardous Substances Data 50-28-2(Hazardous Substances Data)

Details:

Estradiol Usage And Synthesis
Indications and Usage Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
Adverse reactions In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
Contradictions Do not use on breasts, vaginal area and vaginal mucosa.
Chemical Properties White Crystalline Powder
Uses Potent mammalian estrogenic hormone produced by the ovary.
Uses Estradiol is the major estrogen secreted by the premenopausal ovary.
Definition ChEBI: The 17beta-isomer of estradiol.
Biological Activity Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.
Estradiol Preparation Products And Raw materials
Raw materials Nitrogen-->p-Toluenesulfonic acid-->Litium-->Potassium borohydride-->Biphenyl-->Acetylacetone-->1,3,5(10)-Estratrien-3-ol-17-one-->Diphenylmethane-->4-ETHYL-2-METHYLPYRIDINE-->ADD