Sevelamer hydrochloride

Min.Order / FOB Price:Get Latest Price

1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 99% purity
Payment Terms : T/T,Other

Keywords

152751-57-0 Sevelamer hydrochloride 99% purity

Quick Details

Appearance:powder
Application:Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.
PackAge:According to the need of packing
ProductionCapacity:100|Kilogram|Month
Storage:Sealed in dry,Room Temperature
Transportation:air,sea,courier

Superiority:

Sevelamer hydrochloride Basic information

Product Name: Sevelamer hydrochloride
Synonyms: SEVELAMER HCL;Sevelemar;Sevelamer Hydrochloride;2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride;(ChloroMethyl)oxirane polyMer with 2-Propen-1-aMine Hydrochloride;2-Propen-1-aMine Hydrochloride polyMer with 2-(ChloroMethyl)oxirane;AllylaMine Hydrochloride-epichlorohydrin CopolyMer;SevelaMer HCL API
CAS: 152751-57-0
MF: C6H12ClNO
MW: 149.61858
EINECS:
Product Categories: Pharmaceutical intermediate;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs
Mol File: 152751-57-0.mol

Details:

Originator   Renagel,Chugai Pharmaceutical
Uses   Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.
Uses   Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.
Manufacturing Process   Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w, 208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h and filtered to a 2500 L reactor. The transfer line was rinsed with water (217 kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for 1.5 h and then heated to reflux for 16 h. The resulting product slurry may be isolated and washed in decanter centrifuge.
Brand name   Renagel (Genzyme).
Therapeutic Function   Antihyperphosphatemic
Veterinary Drugs and Treatments   Sevalamer may be useful for treating hyperphosphatemia associated with chronic renal failure, particularly when oral aluminum salts are not tolerated.

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