High quality CAS:936091-26-8 in stock

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1 Kilogram	FOB Price: USD 1000.0000

1 Kilogram

FOB Price: USD 1000.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,

Keywords

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide TG 101348 SAR302503

Quick Details

Appearance:white powder
Application:An orally available inhibitor of Janus kinase 2 (JAK-2) developed for the treatment of patients with myeloproliferative diseases including myelofibrosis.
PackAge:1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order 25kg/drum for commercial quantity or specific packing required by customer.
ProductionCapacity:10|Metric Ton|Month
Storage:stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Transportation:Safe shipping by sea EMS FEDEX DHL

Superiority:

TG101348 (SAR302503) is an orally available inhibitor of Janus kinase 2 (JAK-2) developed for the treatment of patients with myeloproliferative diseases including myelofibrosis. TG101348 acts as a competitive inhibitor of protein kinase JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also sensitive, with IC50=25 nM and IC50=17 nM, respectively. Significantly less activity was observed against other tyrosine kinases including JAK3 (IC50=169 nM).[1] In treated cells the inhibitor blocks downstream cellular signalling (JAK-STAT) leading to suppression of proliferation and induction of apoptosis.

Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms. Patients with myelofibrosis frequently harbor JAK-STAT activating mutations that are sensitive to TG101348. Phase I trial results focused on safety and efficacy of TG101348 in patients with high- or intermediate-risk primary or post–polycythemia vera/essential thrombocythemia myelofibrosis have been published in 2011.

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CAS No.:	936091-26-8	Other Names:	936091-26-8	MF:	936091-26-8
EINECS No.:	936091-26-8	Place of Origin:	China (Mainland)	Type:	Auxiliaries and Other Medicinal Chemical
Grade Standard:	Medicine Grade	Brand Name:		Model Number:	API
Purity:	99%	USAGE:	pharmaceutical raw materials	Appearance:	powder
Shelf life:	2 years	Assay:	99% min	Inventory status:	in stock
Spectrum:	Available	MSDS:	Available	COA:	Available