CasNo.2353-33-5,Decitabine,(2353-33-5) Suppliers

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Purity: 99%
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Keywords

Decitabine 4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on 4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one

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Application:Anti-cancer
PackAge:25kg/drum
ProductionCapacity:|Metric Ton|Day
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5-Aza-2'-deoxycytidine Basic information

Product Name:	5-Aza-2'-deoxycytidine
Synonyms:	4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on;4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one;5-azadeoxycytidine;5-triazin-2(1h)-one,4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-3;2'-DEOXY-5-AZACYTIDINE;4-AMINO-1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-1,3,5-TRIAZIN-2(1H)-ONE;5-AZA-2'-DEOXYCYTIDINE;5-AZA-CDR
CAS:	2353-33-5
MF:	C8H12N4O4
MW:	228.21
EINECS:	219-089-4
Product Categories:	API;Bases & Related Reagents;Nucleotides;analog of cytosine;Intermediates & Fine Chemicals;Pharmaceuticals;Epigenetics;Inhibitor;Deoxycytidine;Anti-cancer&immunity
Mol File:	2353-33-5.mol

5-Aza-2'-deoxycytidine Chemical Properties

mp	~200 °C (dec.)
storage temp.	−20°C
solubility	acetic acid/water (1:1): 50 mg/mL
Merck	13,2873
Stability:	Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference	2353-33-5(CAS DataBase Reference)
EPA Substance Registry System	1,3,5-Triazin-2( 1H)-one, 4-amino-1-(2-deoxy-.beta.- D-erythro-pentofuranosyl)- (2353-33-5)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	XZ3012000
F	10-34

MSDS Information

Provider	Language
5-Aza-2'-deoxycytidine	English
SigmaAldrich	English

5-Aza-2'-deoxycytidine Usage And Synthesis

Chemical Properties	white crystalline powder
Usage	Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.
Usage	Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively
General Description	Fine white crystalline powder. Used as a drug.
Air & Water Reactions	Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour .
Reactivity Profile	5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard	Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible.
Biological Activity	Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation