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Omeprazole Usage And Synthesis |
Chemical Properties | White Crystalline Solid |
Usage | Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative |
Usage | diuretic, sweetener, diagnostic aid |
Biological Activity | H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell). |
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