AZD1152-HQPA

Min.Order / FOB Price:Get Latest Price

50 Milligram	Negotiable

50 Milligram

Negotiable

Min.Order :50 Milligram
Purity: ＞98％
Payment Terms : T/T,Other

Keywords

AZD1152-HQPA 722544-51-6 AZD1152-HQPA 722544-51-6 Barasertib

Quick Details

Appearance:Off-white solid
Application:laboratory research
PackAge:As your request
ProductionCapacity:|Metric Ton|Day
Storage:RT
Transportation:by air

Superiority:

High purity

NMR、HPLC will be offered

Fast delivery

Custom synthesis is available

Details:

AZD-1152 is a novel acetanilide-substituted pyrazole-aminoquinazoline prodrug that is converted rapidly to the active drug AZD-1152 hydroxy-QPA (AZD1152-HQPA) in human plasma. AZD1152-HQPA is a specific inhibitor of the enzymatic activity of Aurora kinase, with selectivity for Aurora B (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively); the inhibitor had even less activity against a panel of greater than 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl. Preliminary studies showed that AZD-1152 was active against a variety of solid tumors including colon, breast,and lung cancers.

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