CasNo.2627-69-2,Aicar,(2627-69-2) Suppliers

1 Kilogram	FOB Price: USD 1.0000

Min.Order :1 Kilogram
Purity: 85.0-99.8%
Payment Terms : T/T,Other

Keywords

Coreychem Important product Advanced and completed testing facilities High Cost-Effective

Quick Details

Appearance:ask
Application:intermediates
PackAge:foil aluminium bag/vacuum packing
ProductionCapacity:130|Kilogram|Week
Storage:Keep in dry and cool condition
Transportation:by air or by sea

Superiority:

Product Name:	AICAR
Synonyms:	ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;1-Deoxy-1-[(4-carbamoyl-5-amino-1H-imidazole)-1-yl]-β-D-ribofuranose;1-β-D-Ribofuranosyl-5-amino-1H-imidazole-4-carboxamide;5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide;AICA-β-D-Riboside
CAS:	2627-69-2
MF:	C9H14N4O5
MW:	258.23
EINECS:	220-097-5
Product Categories:	ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;PI3K;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Akt;mTOR
Mol File:	2627-69-2.mol

AICAR Chemical Properties

Melting point	214-215 °C
storage temp.	−20°C
solubility	H₂O: >10 mg/mL
form	powder
color	tan
Water Solubility	Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax	265nm(NaOH)(lit.)
Merck	14,16
InChIKey	RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference	2627-69-2(CAS DataBase Reference)
EPA Substance Registry System	1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)

Safety Information

Hazard Codes	Xi,T
Risk Statements	36/37/38-61
Safety Statements	26-36-45-53
WGK Germany	3
TSCA	Yes
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English

AICAR Usage And Synthesis

adenosine regulating agents	Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties	Solid
Uses	glucose uptake stimulant; AMPK activator
Uses	AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Definition	ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Biological Activity	Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Details:

Risk Statements:R36/37/38
Hazard Codes:Xi: Irritant;
CAS No.:2627-69-2
Synonyms:View MoreArasine; Acadesine,AICA; AICA-RIBOSIDE; GP 1-110; Acadesine; AMPK; AIC-Riboside; 5-amino-4-imidazole carboxamide ribonucleoside; ACADESINE; Z-RIBOSIDE;
Formula:C9H14N4O5
Exact Mass:258.09600
Molecular Weight:258.23100
PSA:156.85000
LogP:-1.54280

Aicar
CAS No.:	2627-69-2
Synonyms:	View More Arasine; Acadesine,AICA; AICA-RIBOSIDE; GP 1-110; Acadesine; AMPK; AIC-Riboside; 5-amino-4-imidazole carboxamide ribonucleoside; ACADESINE; Z-RIBOSIDE;
Formula:	C9H14N4O5
Exact Mass:	258.09600
Molecular Weight:	258.23100
PSA:	156.85000
LogP:	-1.54280

Properties
Melting Point:	214-215oC
Boiling Point:	726.3oC at 760 mmHg
Density:	2.06 g/cm3
Storage Temp:	-20oC
Flash Point:	393.1oC
Appearance:	Solid
Vapor Pressure:	3.83E-22mmHg at 25C
Refractive Index:	1.821
Clear solution:
Freezing Point:
Ignition Point:
Stability:
Vapor Density:
Water Solubility:
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Safety Info
Safety Statements:	26-36
WGK Germany:	3
Risk Statements:	R36/37/38
Hazard Codes:	Xi: Irritant;
HS Code:
Hazard Class:
Packing Group:
RIDADR:
RTECS:

Henan CoreyChem Co., Ltd, facing global High-tech pharmaceutical raw materials, high value-added new type intermediates fine chemicals custom synthesis, scale-up production and rare chemicals trade. We have experienced research staff, strong technical force, well-equipped machine, and considerate marketing team service, with a strict customer intellectual property security system, we are already become good partner of customers from difficult and complex chemical and biological chemical field. Our high quality & low price and effective services shortened new product development cycle,reduced the development and production cost for numerous partners.

The company has completed numerous domestic and overseas famous pharmaceutical, chemical, biological and other large and medium-sized company R&D outsourcing services, synthesis process development and optimization services, chemical intermediates customized service, special chemical processing and production services, etc., We hope to become continuous mutually beneficial partnership with you, to create a better business opportunities together.

Service Scope:

1. Samples synthetic, Our strong r&d team has accumulated abundant experience in synthesis design and exploring synthesis of new technology. Not only good at heterocyclic chemistry, chiral chemicals (asymmetric synthesis and enzyme reaction), metal organic synthesis, high throughput chemistry, also specializes in bioorganic chemistry including nucleosides, nucleotides, sugar chemical, peptide chemistry, etc, to complete the synthesis from mg to kg samples in lab scale. Our efficient management and good communication skills and ability to solve the problem rapidly in order to ensure quality, timely delivery, based on the standard client confidential system and competitive price products,we has been recognized and praised by many customers in chemical industry.

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