Naproxen

Naproxen

Naproxen

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1 Kiloliter

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  • Min.Order :1 Kiloliter
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

()-2-(methoxy-2-naphthyl)-propionicacid C14H14O3 22204-53-1

Quick Details

  • Appearance:white to light yellow crystal powde
  • Application:In medicine, dyes intermediates
  • PackAge:As required
  • ProductionCapacity:5|Metric Ton|Month
  • Storage:Ventilated, dry and cool
  • Transportation:by sea or by air

Superiority:

Changzhou Xuanming Chemical Co., Ltd. is dedicated to the technology development, manufacturing, import and export chemicals, which are specialized in pharmaceutical intermediates, pesticide intermediate, industry of fine chemicals and custom synthesis. Now, we enjoy good reputation among customers and take favorable market share in domestic and at abroad.

Changzhou Xuanming Chemical CO., LTD is located in Northern Jiangshu Industry Park, we have modern manufacture bases and some laboratories, which can supply the key intermediate for your projects, and short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard. We have been abided by “treat technology as first, quality as basis, customers as God, and be honest and sincere”. It is our final aim to provide environmental and high technological products and meet customers’ requirements according to keep effors on developing new chemical fields.

Changzhou Xuanming Chemical CO., LTD promises to help you with heart and soul.

 

Details:

Naproxen Basic information
Non-steroidal anti-inflammatory drugs Chemical Properties Uses Used in Particular Diseases production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name: Naproxen
Synonyms: ()-2-(methoxy-2-naphthyl)-propionicacid;()-2-(methoxy-2-naphthyl)-propionsaeure;()-propionicaci;(+)-2-(Methoxy-2-naphthyl)-propionic acid;(+)-2-(methoxy-2-naphthyl)-propionicacid;(+)-2-(Methoxy-2-naphthyl)-propionsaeure;(+)-2-naphthaleneaceticaci;(+)-6-Methoxy-alpha-methyl-2-napthaleneacetic acid
CAS: 22204-53-1
MF: C14H14O3
MW: 230.26
EINECS: 244-838-7
Product Categories: chiral;Carboxylic Acids (Chiral);Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;-;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Aromatics;ALEVE;Other APIs
Mol File: 22204-53-1.mol
Naproxen Structure
 
Naproxen Chemical Properties
Melting point  152-154 °C(lit.)
alpha  D +66° (in chloroform)
Boiling point  332.25°C (rough estimate)
density  1.1450 (rough estimate)
refractive index  67.5 ° (C=1, CHCl3)
Fp  9℃
storage temp.  -20°C Freezer
solubility  Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
form  powder
pka pKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain)
optical activity [α]25/D +66°, c = 1 in chloroform
Water Solubility  Insoluble in water.
Merck  14,6417
BRN  3591067
CAS DataBase Reference 22204-53-1(CAS DataBase Reference)
NIST Chemistry Reference Naproxen(22204-53-1)
 
Safety Information
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  36/37-45-16-7-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UF5275000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29189900
Hazardous Substances Data 22204-53-1(Hazardous Substances Data)
Toxicity LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski)
Naproxen Usage And Synthesis
Non-steroidal anti-inflammatory drugs Naproxen is a non-steroidal anti-inflammatory drug ,it is a PG synthase inhibitor, which can inhibit prostaglandin synthetase, it has significant analgesic and antipyretic effects, oral absorption is rapid and complete, 2 to 4 hours after a dose ,plasma concentration reaches the peak, in the blood , more than 99% is bound to plasma proteins, t1/2 is 13 to 14 hours, about 95% is discharged from the urine with the prototype and metabolites.it is clinically used For the treatment of rheumatic and rheumatoid arthritis , osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.it can also be used to alleviate pain caused by musculoskeletal sprains, contusions,damages and dysmenorrhea . But it should be noted that like other non-steroidal anti-inflammatory drugs, the same serious gastrointestinal adverse reactions could occur at any time while taking naproxen during treatment, so the active gastroduodenal ulcer patients are hanged, other gastrointestinal tract disease patients should take this drug under close medical supervision.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical Properties White crystal or crystalline powder. Melting point 155.3 ℃. Soluble in acetone, soluble in methanol, ethanol, acetic acid, insoluble in benzene, practically insoluble in water. In case of light,it is color-graded, odorless, tasteless.
Uses It is a non-steroidal anti-inflammatory drug for the relief of fever and inflammation and pain associated with arthritis or other symptoms , it has anti-inflammatory, antipyretic and analgesic effects. Naproxen plays a role by inhibiting the cyclooxygenase, which generates prostaglandin and is one kind of enzymes related to inflammatory mediators . It is recommended to take the drug during meals to reduce stomach irritation.
Used in Particular Diseases Acute Gouty Arthritis:
Dosage and Frequency: 500 mg twice daily for 3 days, then 250–500 mg daily for 4–7 days
production method by methylation, acetylation With 2-naphthol , 6-methoxy-2-acetonaphthone is produced, then it is condensed with acid ester, then generate the product through isomerization, hydrolysis, oxidation, and split and other reactions.
Category Toxic substances
Toxicity grading Highly toxic
Acute toxicity Oral-rat LD50 248 mg/kg; Oral-Mouse LD50: 360 mg/kg
Flammability and hazard characteristics Combustible; combustion produces toxic and acrid smoke.
Storage Characteristics Ventilated, low-temperature ,dry storeroom, it should be stored and transported from food raw materials separately.
Extinguishing agent Water, dry powder, foam,sand
Chemical Properties white to light yellow crystal powde
Uses An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
Indications Naproxen (Naprosyn) also has pharmacological properties and clinical uses similar to those of ibuprofen. It exhibits approximately equal selectivity for COX-1 and COX-2 and is better tolerated than certain NSAIDs, such as indomethacin. Adverse reactions related to the GI tract occur in about 14% of all patients, and severe GI bleeding has been reported. CNS complaints (headache, dizziness, drowsiness), dermatological effects (pruritus, skin eruptions, echinoses), tinnitus, edema, and dyspnea also occur.
Definition ChEBI: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such a osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Brand name Naprosyn (Roche).
General Description Naproxen (Naprosyn, Anaprox), marketed as the (S)-enantiomer,is well absorbed after oral administration, givingpeak plasma levels in 2 to 4 hours and a half-life of 13 hours.Naproxen is highly protein bound and displaces most protein-bound drugs. It is recommended for use in RA, OA, acute gouty inflammation, and in primary dysmenorrhea. Itshows good analgesic activity (i.e., 400 mg is comparable to75–150 mg of oral meperidine and superior to 65 mg ofpropoxyphene and 325 mg of aspirin plus 30 mg of codeine).It is also available OTC as 200-mg tablets (Aleve).
Veterinary Drugs and Treatments The manufacturer lists the following indications: “…for the relief of inflammation and associated pain and lameness exhibited with myositis and other soft tissue diseases of the musculoskeletal system of the horse.” (Package Insert; Equiproxen—Syntex). It has also been used as an antiinflammatory/analgesic in dogs for the treatment of osteoarthritis and other musculoskeletal inflammatory diseases (see adverse reactions below).

 

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