PD 0325901 N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE;PD 0325901;(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide;PD-0235901;N-[(2R)-2, 391210-10-9
PD0325901 is a selective MEK1 and MEK2 inhibitor. PD0325901 inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). PD0325901 inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. PD0325901 also inhibits production of proangiogenic cytokines such as VEGF. Orally active.
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