NSC 14613

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100 Gram	FOB Price: USD 1.0000

100 Gram

FOB Price: USD 1.0000

Min.Order :100 Gram
Purity: 98%
Payment Terms : L/C

Keywords

PluriSln 1 4-Pyridinecarboxylicacid, 2-phenylhydrazide;plurisln 1;NSC 14613;PluriSIn#1;PluriSln 1, NSC 14613;PluriSIn #1 (NSC 14613);NSC 14613, PluriSln 1;4-Pyridinecarboxylic acid 2-phenylhydrazide PluriSln 1 N 91396-88-2

Quick Details

Appearance:White crystal
Application:CAS：91396-88-2； 4-Pyridinecarboxylicacid, 2-phenylhydrazide;plurisln 1;NSC 14613;PluriSIn#1;PluriSln 1, NSC 14613;PluriSIn #1 (NSC 14613);NSC 14613, PluriSln 1;4-Pyridinecarboxylic acid 2-phenylhyd
PackAge:100g,500g,1kg,25kg
ProductionCapacity:1000|Gram|Month
Storage:Dry seal
Transportation:shipping

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Details:

PluriSln 1(NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.
IC50 Value:
Target: SCD1
in vitro: Cellular and molecular analyses demonstrated that the most selective compound, PluriSIn #1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs. Close examination identified this molecule as an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. PluriSIn #1 was also cytotoxic to mouse blastocysts, indicating that the dependence on oleate is inherent to the pluripotent state. Finally, application of PluriSIn #1 prevented teratoma formation from tumorigenic undifferentiated cells [1].
in vivo:

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