Reversine,

Reversine,

Reversine,

Min.Order / FOB Price:Get Latest Price

100 Gram

FOB Price: USD 1.0000

  • Min.Order :100 Gram
  • Purity: 98%
  • Payment Terms : L/C

Keywords

Reversine, Reversine, 656820-32-5

Quick Details

  • Appearance:close to white solid
  • Application:CAS:656820-32-5; Small molecule inhibitors ,natural product ;
  • PackAge:100g,500g,1kg,25kg
  • ProductionCapacity:1000|Gram|Month
  • Storage:refrigerate
  • Transportation:shipping

Superiority:

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.
 
 
 

We are committed to provide excellence in researching, manufacturing and drug discovery process.
 
 
 

Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.

 

Details:

Reversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C with IC50s of 150-500 nM.
IC50 Value: 150 nM (Aurora Kinase A); 500 nM (Aurora Kinase B); 400 nM (Aurora Kinase C) [1]
Target: pan-Aurora Kinase
in vitro: Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9. Use of a pan-caspase inhibitor before treatment with reversine attenuated cell death [2]. Reversine significantly suppressed the proliferation of two OSCC cell lines (OC2 and OCSL) and markedly rendered cell cycle arrest at G2/M stage. Reversine also induced cell death via both caspase-dependent and -independent apoptosis. In addition,reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy [3]. Reversine pre-treatment, at very low concentration (50 nM), caused a marked increase in the differentiation yields of both BMSCs and ASCs [4].
in vivo: In the therapeutic mouse model, tumor weight and tumor volume of cervical cancer bearing mice was more reduced when compared with the control agents (P < 0.05) in tumor-bearing mice [5].

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