Reversine, Reversine, 656820-32-5
Reversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C with IC50s of 150-500 nM.
IC50 Value: 150 nM (Aurora Kinase A); 500 nM (Aurora Kinase B); 400 nM (Aurora Kinase C) [1]
Target: pan-Aurora Kinase
in vitro: Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9. Use of a pan-caspase inhibitor before treatment with reversine attenuated cell death [2]. Reversine significantly suppressed the proliferation of two OSCC cell lines (OC2 and OCSL) and markedly rendered cell cycle arrest at G2/M stage. Reversine also induced cell death via both caspase-dependent and -independent apoptosis. In addition,reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy [3]. Reversine pre-treatment, at very low concentration (50 nM), caused a marked increase in the differentiation yields of both BMSCs and ASCs [4].
in vivo: In the therapeutic mouse model, tumor weight and tumor volume of cervical cancer bearing mice was more reduced when compared with the control agents (P < 0.05) in tumor-bearing mice [5].
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