VU 0361737

Min.Order / FOB Price:Get Latest Price

100 Gram	FOB Price: USD 1.0000

100 Gram

FOB Price: USD 1.0000

Min.Order :100 Gram
Purity: 98%
Payment Terms : L/C

Keywords

VU 0361737 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide;VU 0361737;2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-;CID-44191096;ML128 1161205-04-4

Quick Details

Appearance:light yellow solid
Application:CAS:1161205-04-4; small molecule inhibitor
PackAge:100g,500,1kg.....
ProductionCapacity:1000|Gram|Month
Storage:Dry seal
Transportation:shipping

Superiority:

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Details:

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.
IC50 value: 110 nM (EC50, for rat ), 240 nM (EC50, for human)
Target: mGlu4
in vitro: VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. [3]
in vivo: VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1). [3]

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