CK-636

Min.Order / FOB Price:Get Latest Price

100 Gram	FOB Price: USD 1.0000

100 Gram

FOB Price: USD 1.0000

Min.Order :100 Gram
Purity: 98%
Payment Terms : L/C

Keywords

CK-636 CK-636;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;CK-0944636;CK-636 N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamid 442632-72-6

Quick Details

Appearance:off white powder
Application:CAS：442632-72-6； Small molecule inhibitors
PackAge:100g,500g,1kg,25kg/drum
ProductionCapacity:1000|Gram|Week
Storage:Dry seal
Transportation:shipping

Superiority:

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.

We are committed to provide excellence in researching, manufacturing and drug discovery process.

Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.

Details:

CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. Inhibits actin polymerization (IC50=22μM).
IC50 value: 4/24/32 uM (Human/fission yeast/bovine Arp2/3) [1]
Target: Arp2/3 complex; actin polymerization
CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

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