TTP 22 TTP 22;Propanoic acid, 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]-;3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid;TTP 22 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidi 329907-28-0
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM; shows selectivity for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM).
IC50 Value: 0.1 uM
Target: CK2
TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 μM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
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