- Min.Order :100 Gram
- Purity: 98%
- Payment Terms : L/C
Keywords
APD668 APD668;APD668 ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE;isopropyl 4-((1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyri 832714-46-2
Quick Details
- Appearance:close to white solid
- Application:CAS：832714-46-2； Small molecule inhibitors
- PackAge:100g,500g,1kg,25kg/drum
- ProductionCapacity:1000|Gram|Week
- Storage:Dry seal
- Transportation:shipping
Superiority:
≥98%
Details:
APD668的生物活性
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively..
IC50 value: 2.7 nM (EC50) [1]
Target: GPR119
Chronic treatment withAPD668 showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels could be significantly reduced in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing. APD668 was the first compound with this mechanism of action to be progressed into clinical development for the treatment of diabetes.
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