NG-52, NG-52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;COMPOUND 52;2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpuri 212779-48-1
NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).
IC50 value: 7 uM [1]
Target: Cdc28p
Compound 52 inhibited growth in a drug-sensitized yeast strain
with a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).
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