Losartan potassium Losartan potassium 124750-99-8
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1.Product description
Product Name: Losartan potassium
CAS: 124750-99-8
MF: C22H23ClKN6O
MW: 462.01
2.Physical properties
Appearance:white crystaliinr powder
Solubility:
Freely soluble in water, soluble in Isopropyl
Alcohol, slightly soluble in Acetonitrile
3.Specification
Item |
Standards |
Results |
Characters |
White or almost white crystalline powder |
White crystalline powder |
Identification |
Infrared absorption: Must similar to reference standard |
Conforms |
Ultraviolet absorption: Must similar to reference standard |
Conforms |
|
Test for potassium: Must be positive |
Positive |
|
Water |
NMT 0.5% |
0.1% |
Heavy metals |
NMT 0.001% |
Conforms |
Chromatographic purity |
Any individual impurity NMT 0.2% |
0.01% |
Total impurities NMT 0.5% |
0.04% |
|
Residual solvents |
Cyclohexane NMT 0.1% |
0.007% |
Isopropyl alcohol NMT 0.2% |
0.03% |
|
Assay(HPLC) |
98.5~101.0% |
99.2% |
4.Application
Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end
organ responses to angiotensin II. Losartan administration results in a decrease in total peripheral resistance
(afterload) and cardiac venous return (preload) All of the physiological effects of angiotensin II, including stimulation
of release of aldosterone, are antagonized in the presence of losartan. Reduction in blood pressure occurs independently
of the status of the renin angiotensin system. As a result of losartan dosing, plasma renin activity increases due to removal of the angiotensin II feedback.
Losartan is a uricosuric. Because losartan can cause hyperkalemia, potassium supplements or salt substitutes containing potassium
should not be used without appropriate monitoring by a physician.
5.Packing
25KG/Drum or as per your requirement
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