Amlodipine besilate Amlodipine besilate 111470-99-6
Our Advantages:
GMP factory
Full experience of large numbers containers loading in main Chinese seaports
Packing with pallet as buyer's special request
Best service after shipment with e-mail
Cargos together with container sales seervice available
Rich experience for exporting
Cargos photo before and after loading into container
Raw materials from chinese origin
Hefei TNJ Chemical Industry Co., limited(ISO 9001: 2008), are strong in the field of Pharmaceuticals,
food additives, plant extract and fine chemicals for more than 10 years.
Service we can provide:
1). Mixed container: We can mix different items in one container.
2). Quality control: Before shipment, we can provide free sample for test. Inspection before shipping.
3). Packing: We can pack according to your requirements and also give you some other packing methods for reference and suggest adequate packing methods according to global trend. We will send you photo of goods before shipment.
4). Prompt shipment: We usually can ship the goods within 7 days for 1*20'FCL conatiner after order confirmed and also provide professional shipping documents for your Customs clearance.
5). We work closely with DHL, FEDEX, UPS,ETC., we can ship samples and small quantity goods to you fast and safe.
We work closely with famous airline companies like BA,PO,OZ,CX,UPS,LA,TG,TA,ET,etc. and professional vessel companies like MSK,"K"LINE,CMA,CSAV,ZIM,WANHAI,HAMBURG-SUD,etc. We can ship bulk quantity to you quick and safe.
6). We can provide door to door shipment in many countries.
1.Product description
Product Name: Amlodipine besilate
CAS: 111470-99-6
MF: C26H31ClN2O8S
MW: 567.05
2.Physical properties
(1) Melting Point: 199-201 °C
(2) solubility: DMSO: 20 mg/mL
(3) Flash Point: 272.6 °C
(4) Enthalpy of Vaporization: 80.17 kJ/mol
(5) Boiling Point: 527.2 °C at 760 mmHg
(6) Vapour Pressure of Amlodipine besylate:3.34E-11 mmHg at 25 °C
3.Specification
Specification |
|
Appearance |
White or almost white powder |
Identification |
Meets the requirements |
Specific Rotation |
-0.10 ~ +0.10° |
Water |
≤0.5% |
Heavy Metals |
≤0.002% |
Redidue in Ignition |
≤0.2% |
Related Substances |
Meets the requirements |
Benzene Sulfonic Acid |
27.3 ~ 28.7% |
Ethanol |
≤300ppm |
Toluene |
≤60ppm |
Benzene |
≤2ppm |
Acetic Acid |
≤600ppm |
Methylamine |
≤20ppm |
Ethyl Benzene Sulfonate |
≤5ppm |
Particle Size |
Meets the requirements |
Assay |
98.0 ~102.0% |
Standard |
USP33 |
4.Application
A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
Angiotensin II inhibitor prodrug, antihypertensive
Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
Biological Activity L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
5.Packing
25KG/Drum or as per your requirement
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