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Sodium cyanoborohydride Sodium cyanoborohydride 25895-60-7
Description:
Product name: Sodium cyanoborohydride
Cas no.: 25895-60-7
Synonyms:
Sodium cyanotrihydroborate; Sodium cyanotrihydridoborate; boron sodium cyanide hydride (1:1:1:3);
sodium (cyano-kappaC)(trihydrido) borate(1-)
Usage:
Owing to the presence of the electron-withdrawing cyanide substituent, [B(CN)H3]− is far less reducing
than is [BH4]−, as found in sodium borohydride. As a mild reducing agent, it is especially used to convert
imines to amines.
It is especially favored for reductive aminations, wherein aldehydes or ketones are treated with an amine
in the presence of this reagent:
R2CO + R'NH2 + NaBH3CN + CH3OH → R2CH-NHR' + "NaCH3OBH2CN"
The reagent is typically used in excess. Selectivity is achieved at mildly basic solutions (pH 7-10). The reagent is ideal for reductive aminations ("Borch Reaction"). In conjunction with tosylhydrazine, sodium cyanoborohydride is used in the reductive deoxygenation of ketones.
Chemical Properties:
Appearance: white to off-white powder, hygroscopic
Molecular formula: CH3BNNa
Molecular Weight: 62.842
Density: 1.20 g/cm3
Melting Point (ºC): 242 ºC
Boiling Point (ºC): 307 ºC
Water Solubility: 2120 g/L at 29 ºC (dec.)
Applications:
Selective reducing agent for aldehydes, ketones, oximes, enamines
Specifications:
Product name | Sodium cyanoborohydride |
Cas no. | 25895-60-7 |
Molecular formula | CH3BNNa |
Structure | |
Appearance | white to off-white powder, hygroscopic |
Assay | 95% min |
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