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ASPARAGINASE L-ASPARAGINASE cas:9015-68-3
Product Name: L-Asparaginase
CAS NO: 9015-68-3
Molecular Formula: C24H24Cl3N3O6
Formula Weight: 556.8229
Appearance: White frozen-dried powder
Assay: 99.0% Min
Introduction
Asparaginase is an enzyme that catalyzes the hydrolysis of asparagineto aspartic acid. Asparaginases are naturally occurring enzymes expressed and produced by microorganisms.
Function
Different types of asparaginases can be used for different industrial and pharmaceutical purposes.
Medical
A different asparaginase is marketed as a drug under the brand name Elspar for the treatment of acute lymphoblastic leukemia (ALL) and is also used in some mast cell tumor protocols. Unlike most of otherchemotherapy agents, it can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation.
Manufacturing
The most common use of asparaginases is as a processing aid in the manufacture of food. Marketed under the brand names Acrylaway and Prevent ASe, asparaginases are used as a food processing aid to reduce the formation ofacrylamide, a suspected carcinogen, in starchy food products such as snacks and biscuits.
Test Items |
Prescribed Standards |
Test Results |
Appearance |
White frozen-dried lump or powder |
complied |
(1)Identification Chemical |
Positive reaction |
complied |
(2) HPLC |
Identical retention time |
complied |
Assay |
||
pH value |
6.5——7.5 |
7.4 |
purity |
not less than 97% |
99.00% |
loss on dry |
not more than 5% |
2.90% |
undue toxicity |
shall complies |
complied |
endotoxin |
< 0.015EU / IU |
complied |
visible extraneous substance |
Shall complies |
complied |
Insoluble particle |
Shall complies |
complied |
Depressor substance |
Shall complies |
complied |
Heavy metal |
Not more than 20ppm |
2ppm |
fill test |
±15% of average fill |
complied |
potency |
85%—115% |
110.80% |
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