Toltrazuril for Coccidiostat Effect

Details:

Toltrazuril
CAS: 69004-03-1
MF: C18H14F3N3O4S
MW: 425.38
Toltrazuril Chemical Properties
MP 194-196° C
Storage temp. 0-6° C
Chemical Properties White Solid
Usage tranquilizer
Usage Labelled analog of a triazinetrione anticoccidial. Coccidiostat.


Toltrazuril (trade names Baycox and Tolcox ) is a coccidiostat.

Toltrazuril - Mode of Action
Toltrazuril (Baycox) damages all intracellular development stages of Eimeria (= Coccidia).

Toltrazuril affects schizonts, micro- and macrogametes, but not the tissue cells of the host animals, as was shown in light and electron microscopic studies.

These findings suggest that toltrazuril interferes with the division of the nucleus and with the activity of the mitochondria, which is responsible for the respiratory metabolism of Coccidia.

In the magrometes, toltrazuril damages the so-called wall-forming bodies. In all intracellular developmental stages, severe vacuolisation occurs due to inflation of the endoplasmatic reticulum.

Toltrazuril thus has a coccidiocidal mode of action.

The special mode of action results in the following advantages:

Toltrazuril acts on all intracellular developmental stages,
Toltrazuril does not interfere with the development of immunity,
Follow-up treatment usually is not necessary,
Even an advanced infection (after 3 - 5 days; Gametogony) can still be treated successfully,
The efficacy of toltrazuril is independent of the severity of the infection.