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1 Kilogram |
Negotiable |
Ursodeoxycholic acid 128-13-2 UDCA
ursodeoxycholic acid udca can be chemically synthesized. Ursodeoxycholic acid reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, Ursodeoxycholic acid has not supplanted surgical treatment by cholecystectomy.
UDCA is used to treat primary biliary cirrhosis. In children, its use is not licensed, as its safety and effectiveness are not established. Ursodeoxycholic acid reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells.
Appearance |
White or almost white powder |
Confirmed |
|
Solubility |
Practially insoluble in water; soluble in methanolchloride. Freely soluble in ethanol(96%),slightlysoluble in acetone |
Complied |
|
Melting Point |
About202°C |
204.0°C |
|
Specific Optical Rotation |
+58° - +62° |
+59.8° |
|
Identification |
|||
ursodeoxycholic acid udca |
Comparable IR absorption with the reference |
Confirmed |
|
The spot is similar in position,colour and size with the reference spot |
Confirmed |
||
A blue-green precipitate occurs. |
Complied |
||
Tests |
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Related Substance |
Lithocholic Acid : n.m.t. 0.1%(TLC) Chenodeoxycholic Acid : n.m.t.1.0% Unspecified impurity: n.m.t. 0.1% Total impurity: n.m.t.1.5% |
Complied Complied Complied Complied |
|
Heavy Mentals |
n.m.t. 20ppm |
Complied |
|
Loss on drying |
n.m.t. 1.0% |
0.13% |
|
Sulphated ash |
n.m.t. 0.1% |
0.07% |
|
Solvents residue |
Methanol: n.m.t. 0.3% Acetone: n.m.t. 0.5% Butylalcohol: n.m.t. 0.5% |
Not detected 0.32% Not detected |
|
Conclusion |
The product complies with the standard of BP2012. |
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