N-Acetylglycinamide

Superiority:

The Acetamide,N-(2-amino-2-oxoethyl)- is an organic compound with the formula .C₄H₈N₂O₂. The IUPAC name of this chemical is 2-acetamidoacetamide. With the CAS registry number 2620-63-5, it is also named as N-(2-Amino-2-oxoethyl)acetamid. Besides, it should be stored in a closed cool and dry place. It is used to treat nervous system diseases.

Physical properties about Acetamide,N-(2-amino-2-oxoethyl)- are: (1)ACD/LogP: -1.87; (2)ACD/LogD (pH 5.5): -1.87; (3)ACD/LogD (pH 7.4): -1.87; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 2.29; (7)ACD/KOC (pH 7.4): 2.29; (8)#H bond acceptors: 4; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 40.62 Å²; (12)Index of Refraction: 1.46; (13)Molar Refractivity: 27.76 cm³; (14)Molar Volume: 101.2 cm³; (15)Polarizability: 11×10^-24cm³; (16)Surface Tension: 42.3 dyne/cm; (17)Density: 1.146 g/cm³; (18)Flash Point: 218.7 °C; (19)Enthalpy of Vaporization: 69.48 kJ/mol; (20)Boiling Point: 438.1 °C at 760 mmHg; (21)Vapour Pressure: 7.11E-08 mmHg at 25°C.

Preparation: this chemical can be prepared by N-acetyl-glycine ethyl ester. This reaction will need reagent water and ammonia.

Uses of Acetamide,N-(2-amino-2-oxoethyl)-: it can be used to produce 6-phenyl-4-thiophen-2-yl-1H-pyridin-2-one at temperature of 140 °C. It will need reagent Cs₂CO₃ and solvent adimethylformamide with reaction time of 1 hour. The yield is about 70%.