2-Chloro-N-(2,6-dimethylphenyl)acetamide

Superiority:

e 2-Chloro-N-(2,6-dimethylphenyl)acetamide, with the CAS registry number 1131-01-7, is also known as N-Chloroacetyl-2,6-dimethylaniline. It belongs to the product categories of Amides; Carbonyl Compounds; Organic Building Blocks; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 214-460-7. This chemical's molecular formula is C₁₀H₁₂ClNO and molecular weight is 197.66. What's more, its systematic name is 2-Chloro-N-(2,6-dimethylphenyl)acetamide. This chemical should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be ensured that the workshop is well ventilated or equipped with exhaust devices. It is used as medical intermediate.

Physical properties of 2-Chloro-N-(2,6-dimethylphenyl)acetamide are: (1)ACD/LogP: 1.465; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.47; (4)ACD/LogD (pH 7.4): 1.47; (5)ACD/BCF (pH 5.5): 7.65; (6)ACD/BCF (pH 7.4): 7.65; (7)ACD/KOC (pH 5.5): 149.33; (8)ACD/KOC (pH 7.4): 149.36; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 29.1 Å²; (13)Index of Refraction: 1.575; (14)Molar Refractivity: 55.024 cm³; (15)Molar Volume: 166.451 cm³; (16)Polarizability: 21.813×10^-24cm³; (17)Surface Tension: 42.4 dyne/cm; (18)Density: 1.187 g/cm³; (19)Flash Point: 145.375 °C; (20)Enthalpy of Vaporization: 55.812 kJ/mol; (21)Boiling Point: 316.766 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation: this chemical can be prepared by chloroacetyl chloride and 2,6-dimethyl-aniline by heating. This reaction will need reagent magnesium oxide and solvent CHCl₃ with the reaction time of 2 hours. The yield is about 86%.

Uses of 2-Chloro-N-(2,6-dimethylphenyl)acetamide: it can be used to produce N-(2,6-dimethyl-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-acetamide at the temperature of 50 °C. It will need reagent K₂CO₃ and solvent tetrahydrofuran with the reaction time of 6 hours. The yield is about 90%.