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Vitamin K1 [r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-
ITEM | STANDARD |
Characteristics |
Clear, yellow to amber, very viscous, odorless or practically odorless liquid, having a specific gravity of about 0.967. Is stable in air, but decomposes on exposure to sunlight. Soluble in dehydrated alcohol, in benzene, in chloroform, in ether, and in vegetable oils; slightly soluble in alcohol; insoluble in water. |
Assay | 97.0-103.0% |
Z Isomer | Not more than 21.0% |
Refractive Index | 1.523~1.526 |
Identification | A. Infrared absorptionB. Ultraviolet absorption Absorptivities at 248nm don't differ by more than 3% |
Reaction | A 1 in 20 solutionof it in dehydrated alcohol is neutral to litmus. |
Limit of menadione | No purple or blue color occurs after dropping it to the solution of Ammonia hydroxide and alcohol. |
Packaging and storage | Preserve in tight, light-resistant containers |
1.This product is the necessary substance for liver to combine the prothrombinase II, VII, IX, X. The shortage of vitamin k1 can caused disorder or abnormal synthesis of prothrombinase.
Clinically, there may be a tendency to bleed to extent the coagulating time.
2.Vitamin k1 also has analgesic and relieving spasm roles. It has obvious effects to cure the angina of visceral unstriped muscle, angina caused by duct cramps and intestinal cramps.
3.In recent years, reports said that High dose vitamin K1 can promote liver cell viability, enhanced monocyte macrophage phagocytosis, so it has a certain effect to chronic hepatitis.
4.As a pharmaceutical, it is widely used in clinical bleeding caused by a lack of vitamin k1, Such as bleeding caused by obstructive jaundice, biliary fistula, chronic diarrhea; low prothrombin
hyperlipidemia caused by Coumarins and sodium salicylate; Hemorrhage of newborn and shortage of vitamin k1 caused by long term use of broad spectrum antibiotics. As a Nutrition Enhancer, it is widely used to produce multi-vitamin foodstuff and livestock fodder.
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