667463-62-9 6BIO C16H10BrN3O2
high quality
BIO Basic information |
Product Name: | BIO |
Synonyms: | 2H-Indol-2-one, 6-broMo-3-[(3E)-1,3-dihydro-3-(hydroxyiMino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-;6BIO;6-bromoindirubin-3-oxime |
CAS: | 667463-62-9 |
MF: | C16H10BrN3O2 |
MW: | 356.178 |
EINECS: | |
Product Categories: | Intracellular Signaling;Inhibitors |
Mol File: | 667463-62-9.mol |
BIO Chemical Properties |
storage temp. | 2-8°C |
solubility | DMSO: >5 mg/mL |
form | solid |
color | dark red |
BIO Usage And Synthesis |
Biological Activity | Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC 50 values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro . |
BIO Preparation Products And Raw materials |
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