Tizanidine Hydrochloride

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 98%
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

64461-82-1 Tizanidine Hydrochloride C9H9Cl2N5S

Quick Details

Appearance:White or off-white Solid
Application:Clinically, it is used to treat the diseases of skeletal muscle tension, muscle spasm and myotonic caused by central injury. It has good effect on tension headache, trigeminal neuralgia and myofascial
PackAge:According to the demand of customer
ProductionCapacity:100|Kilogram|Week
Storage:Desiccate at RT
Transportation:by air or by sea

Superiority:

Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professional development team engaging in the fine chemicals, Henan Allgreen Chemical Co.,Ltd is mainly engaged in development and customized of organic electronic chemical materials, metal catalysts, phosphorus ligands, medical intermediate , chemical reagent and other fine chemical products. We have multifunctional production conditions and could offer high quality products from grams to kilograms and tons. In addition, we absorb new technology actively from colleges and also have established good relations of cooperation with Huazhong University of Science and Technology, Zhengzhou University, Henan Institute of Engineering. Henan Provincial Institute of chemistryand some other well-known domestic enterprises. Our products have been exported to Japan, South Korea, Europe, America and other countries and regions, well received by customers.

With sound management system, we've been authorized the Import&Export qualification by the government and also has passed the “ISO 9001-2008 Quality Management System” certification. We always stand on the quality of product as our life, develop in the direction of customers requirement and aim at creating greater value for customers.Innovation and honesty, we will make common development with the masses of customers at home and abroad hand in hand by our best service.

Threre are more than 30 company teams, including 8 with senior professional titles, and 70% of them have master's degree or above. There are 800 Square meters laboratory and 2000 Square meters pilot plant, equipped with high-temperature and high-pressure reaction system, anhydrous and anaerobic operating system, UHPLC, HPLC, GC, GC-MS, TG-DSC and other instruments and equipment, to meet R&D, production, testing, Packaging and other requirements. Since its establishment, Allgreen has cooperated with many well-known domestic enterprises and many technology-based enterprises to provide them with high-quality products and services

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Details:

Tizanidine hydrochloride Basic information

Description References

Product Name:	Tizanidine hydrochloride
Synonyms:	5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2;1,3-benzothiadiazol-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-mono;5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazolehydrochloride;SIRDALUD;TERNELIN;TIZANIDINE HCL;TIZANIDINE HYDROCHLORIDE;ZANAFLEX
CAS:	64461-82-1
MF:	C9H9Cl2N5S
MW:	290.17
EINECS:
Product Categories:	Zanaflex, Sirdalud;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds;Muscle relaxant (skeletal);Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor
Mol File:	64461-82-1.mol

Tizanidine hydrochloride Chemical Properties

Melting point	280 °C
Fp	9℃
storage temp.	Desiccate at RT
solubility	H₂O: ~29 mg/mL
form	solid
color	white
Merck	14,9485
CAS DataBase Reference	64461-82-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26-36-37/39
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	DK9910000
HS Code	2934990002

MSDS Information

Provider	Language
SigmaAldrich	English

Tizanidine hydrochloride Usage And Synthesis

Description	As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia. As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation.
References	# # # # #
Chemical Properties	Off-White to pale Yellow Solid
Originator	Nimzox,Rapross Pharmaceuticals Pvt. Ltd.,India
Uses	An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal).
Uses	Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,
Uses	Anticoagulant
Manufacturing Process	14 ml of benzoyl chloride are added to a solution of 11.5 g of ammonium thiocyanate in 150 ml of acetone in an ice bath and the mixture is then stirred for 10 min. This solution is heated to the boil at reflux together with 19 g of 4-amino-5-chloro-2,1,3-benzothiadiazole. The solution is cooled to room temperature and diluted with a 4-fold quantity of water. The precipitate is filtered off and rapidly brought to a boil together with 150 ml of a 2 N aqueous sodium hydroxide solution and kept at the boil for 5 min. The solution is cooled to room temperature, is acidified weakly with glacial acetic acid, the precipitate is filtered off, washed with ether and recrystallized from methanol. The N-(5-chloro-2,1,3-benzothiadiazol-4-yl)thiourea, obtained and this is boiled for 1 h together with 9 g of methyl iodide in 150 ml of methanol. After concentrating by evaporation, crude S-methyl-N-(5-chloro-2,1,3- benzothiadiazol-4-yl)isothiuronium iodide is obtained. 9.8 g of S-methyl-N-(5- chloro-2,1,3-benzothiadiazol-4-yl)isothiuronium iodide are heated to the boil at reflux for 1 h together with 50 ml of methanol and 1.8 ml of ethylene diamine. The solvent is then removed by evaporation and the moist residue is boiled at reflux for 1 h together with 20 ml of n-amyl alcohol. The mixture is subsequently shaken with 50 ml of chloroform and 150 ml of water until all the material is dissolved. 40 ml of a 2 N aqueous sodium hydroxide solution are added to the aqueous phase and extraction is effected with 200 ml of chloroform. The organic phase is dried and concentrated by evaporation. After recrystallizing the residue from methanol with the addition of some active charcoal, 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole, having a melting point of 221-223°C, is obtained. The 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole hydrochloride may be obtained by the teaction of 4-(2-imidazolin-2-yl-amino)-5-chloro- 2,1,3-benzothiadiazole with hydrochloric acid.
Brand name	Tizanidine is INN and BAN.
Therapeutic Function	Muscle relaxant, Spasmolytic
Biological Activity	α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor.