CasNo.152121-30-7,SB202190,(152121-30-7) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 99%
Payment Terms : T/T,,MoneyGram

Keywords

152121-30-7 supplier SB202190 p38,MAPK,inhibitor

Quick Details

Appearance:light Yellow solid
Application:for research
PackAge:foil bag
ProductionCapacity:10|Kilogram|Month
Storage:Keep away from fire and heat source;keep in shady, cool and dry condition;protect against the tide
Transportation:DHL\TNT\FEDEX...

Superiority:

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase,SB202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively).

Details:

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase,SB202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively).

References:

[1]. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase.inhibitors. Biochem.J. 351 95.

[2]. Karahashi H et al A selective inhibitor of p38 MAP kinase, SB202190, induced apoptotic cell death of a lipopolysaccharide-treated macrophage-like cell line, J774.1 Biochim Biophys Acta. 2000 Oct 18;1502(2):207-23.

[3]. Winnicki K, Maszewski J.SB202190 affects cell response to hydroxyurea-induced genotoxic tress in root meristems of Vicia faba.Plant Physiol Biochem. 2012 Aug 13;60C:129-136.

[4]. Keshari RS, Verma A, Barthwal MK, Dikshit M.Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA- induced NETs release from human neutrophils.J Cell Biochem.2012 Sep 7.

[5]. Zbinden-Foncea H, Deldicque L, Pierre N, Francaux M, Raymackers JM.TLR2 and TLR4 activation induces p38 MAPK-dependent phosphorylation..