SB203580

SB203580

SB203580

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1 Gram

FOB Price: USD 8000.0000

  • Min.Order :1 Gram
  • Purity: 98%min
  • Payment Terms : T/T,

Keywords

SB203580 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine 152121-47-6

Quick Details

  • Appearance:yellow powder
  • Application:Research purpose
  • PackAge:1kg/Aluminum foil bag
  • ProductionCapacity:500|Kilogram|Month
  • Storage: Kept in a cool, dry and ventilated place
  • Transportation:by air

Superiority:

Prouduct Name:SB203580

Chemical Name:4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine

M.Wt: 377.43

Formula: C21H16FN3OS

appearance:yellow powder

Solubility: Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl

Purity:>98%

Storage: Desiccate at +4°C

CAS No: 152121-47-6

SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.

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Details:

Prouduct Name:SB203580

Chemical Name:4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine

M.Wt: 377.43

Formula: C21H16FN3OS

appearance:yellow powder

Solubility: Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl

Purity:>98%

Storage: Desiccate at +4°C

CAS No: 152121-47-6

SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.

we are the manufacturer of all kinds ofchemicals .We focus on providing customers with high quality products.

Welcome to contact us for more products information and requirement, we will do our best to cooperate with you.

Sample order is appreciated.

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