110078-46-1PLERIXAFORPLERIXAFOR

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1 Kilogram

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110078-46-1 PLERIXAFOR C28H54N8

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PLERIXAFOR Basic information

Product Name:	PLERIXAFOR
Synonyms:	PLERIXAFOR;1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane;1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-;Mozobil;Sdz sid 791;Unii-S915p5499n;1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane;Plerixafor(AMD3100)
CAS:	110078-46-1
MF:	C28H54N8
MW:	502.791
EINECS:
Product Categories:	Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	110078-46-1.mol

PLERIXAFOR Chemical Properties

Safety Information

MSDS Information

PLERIXAFOR Usage And Synthesis

Chemical Properties	White Solid
Usage	Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively
Usage	Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in p atients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).