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Sitagliptin phosphate monohydrate Sitagliptin phosphate 654671-77-9 99.3%
Acid west his dean was first developed by Merck, Germany won the U.S. food and drug administration approved for the treatment of type 2 diabetes dipeptide base peptidase Ⅳ (DDP - 4) inhibitor drugs, is a new type of diabetes, can increase the body's own ability to reduce high blood sugar levels, inhibit the enzyme activity and relatively improve shortness of naturally occurring intestinal insulin, including sample glucagon peptide 1 promote insulin and glucose dependence peptide levels, increased insulin production is triggering the pancreas and the liver to stop glucose production, and finally the clinical effect of lowering blood sugar concentration. The characteristic of this product is in stimulating insulin secretion, at the same time can reduce hungry feeling, and will not put on weight, also won't hypoglycemia and edema occur, suitable for diabetic patients with poor blood sugar control and frequent hypoglycemia. 552 cases of clinically mild-to-moderate patients with type 2 diabetes, take a daily phosphate west he listed, take 100 milligrams, 12 weeks after can reduce glycated hemoglobin 0.6% - 0.6%. Incidence of adverse reactions similar to placebo, the most frequently reported adverse reactions (rate > 5%, and higher than placebo) is blocked or runny nose, headache and sore throat, upper respiratory tract infection, and.
Clinical studies showed that phosphate west his dean as monotherapy in patients with type 2 diabetes, can make the glycosylated hemoglobin (HbA1c) were significantly reduced. Associated with metformin or TZDs applications, has significant auxiliary therapeutic effect, can according to three main defects of type 2 diabetes: insulin resistance, beta cell dysfunction (the release of insulin decrease), and alpha cells dysfunction (not inhibit hepatic glucose production) play a role. But the drug should not be used in patients with type 1 diabetes or the treatment of diabetic ketone acidosis.
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