Fludarabine

Fludarabine
Fludarabine
Fludarabine
Fludarabine
Fludarabine

Fludarabine

Min.Order / FOB Price:Get Latest Price

25 Kilogram

FOB Price:USD 4800.0000 -6000.0000
  • Min.Order :25 Kilogram
  • Purity: 99.5（%）
  • Payment Terms : L/C,T/T,,MoneyGram

Keywords

21679-14-1 Fludarabine 2-Fluoroadenine-9-β-D-arabinofuranoside;

Quick Details

  • Appearance:appearance White powder
  • Application:Widely used in cosmetics, medicine, beauty health food and other industries
  • PackAge:1000 g/aluminum foil bag
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:Dry and ventilated
  • Transportation:shipping

Superiority:

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly  to $2 million, we  have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also  has the advantage of high quality in Africa. in the past two years our products  has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!The quality of our products meet all international standards, the German advanced equipment are imported equipment two laboratories, individual, on scale management concept, our aim is;With the highest quality. The lowest price. The best service to meet the new and old customers around the world, develop together for a better future!

Details:

Keywords

  • good quality ,Fludarabine
  • competitive price ,Fludarabine

Quick Details

  • ProName: Fludarabine
  • CasNo: 21679-14-1
  • Appearance: White Solid
  • Application: medical intermediate
  • DeliveryTime: delivery in 2-3 days after receiving 3...
  • PackAge: in bottle or bucket
  • Port: anyport in China
  • ProductionCapacity: 100 Kilogram/Week
  • Purity: 98%
  • Storage: Store in dark, dry and sealed containe...
  • Transportation: by air or by sea
  • LimitNum: 1 Gram

Superiority

1.factory 2.good quality 3.competitive price 4.MF:C10H12FN5O4

Details

Fludarabine Basic information
Product Name: Fludarabine
Synonyms: 2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE
CAS: 21679-14-1
MF: C10H12FN5O4
MW: 285.23
EINECS: 244-525-5
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;API
Mol File: 21679-14-1.mol

 

Fludarabine Chemical Properties
mp  265-268°C
storage temp.  2-8°C
solubility  DMF: 20 mg/mL, clear, faintly yellow
Merck  13,4152
CAS DataBase Reference 21679-14-1(CAS DataBase Reference)
 
Safety Information
Risk Statements  23/24/25-36/37/38-39/23/24/25-39
Safety Statements  26-36/37-45
WGK Germany  3
RTECS  AU6207000
F  10
Hazardous Substances Data <a title="21679-14-1(Hazardous Substances Data)" dbs+hsdb:@rn+21679-14-1"="" style="margin: 0px auto; padding: 0px; border: 0px;">21679-14-1(Hazardous Substances Data)
Fludarabine Usage Synthesis
Chemical Properties White Solid
Usage Used as an antineoplastic
Usage A STAT-1 activation inhibita DNA synthesis inhibitor. 
Biological Activity Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) triggers apoptosis through increasing Bax decreasing Bid, XIAP survivin expression. Displays anticancer activity against hematological malignancies in vivo .
 
Fludarabine Preparation Products Raw materials
Raw materials Acetic anhydride-->Fluoroboric acid-->Boron trichloride -->2,4,5,6-TETRAAMINOPYRIMIDINE-->2,6-Diaminopurine-->DIACETAMIDE
Fluorine rabin editor
Lack of overview, this entry card figure, add more complete, relevant content to make entry also can rapid upgrade, hurriedly to edit!
Chinese fluorine of rabin optimal rules should be disease of antineoplastic drugs, 50 mg of this product is white or kind of white powder
directory
1 the basic information
2 details
Basic information editing


Fluorine dara shore for injection
Project name: fluorine dara shore for injection
Drug category: medicine six classes
Adapt to:.
Rules:
Project progress: stay at production
Raw material source: legal sources
Case note: this product belongs to the medicine six kind of generic drugs, can declare the production directly.Good market prospect.
Detailed information on the editor


[character].
Pharmacology and toxicology] [fluoride phosphate dara marina for antiviral drugs vidarabine fluoride nucleotide analogues, 9 - beta - D - Arab acid - furan bases adenine (ara - A), can be relatively resistant to adenine deaminase deamination.
Fluoride phosphate dara marina phosphorylation in the body was quickly to become 2 f - ara - A, the latter can be cells to absorb, and then by intracellular DNA cytidine kinase phosphorylation triphosphate become active after 2 f - ara - ATP.The metabolites can inhibit ribonucleic acid reductase, DNA polymerase alpha, delta and & lt;101 & gt;Enzyme, DNA primers and DNA ligase activity to inhibit the synthesis of DNA.Also can partially inhibit the activity of RNA polymerase Ⅱ reducing protein synthesis.
2 f - ara - ATP certain aspects of the mechanism is not clear, mainly through the influence of DNA, RNA and protein synthesis and inhibit the growth of cells, including inhibition of DNA synthesis is its main function.In addition, in vitro studies have shown that chronic lymphocytic leukemia (CLL) lymphocytes in 2 f - ara - A after processing, the widespread of DNA fragmentation and cell apoptosis.
[indication]
B cell chronic lymphocytic leukemia (CLL), in the patients with at least one course of chemotherapy regimens including standard alkylating agent class after treatment or during the period of treatment, the illness did not improve or continue to progress.
[usage]
Adults: fluoride phosphate dara marina should be rich in antineoplastic therapy used under the supervision of experienced doctors.
Strongly recommended fluoride phosphate dara shore can only be used for intravenous injection.Although no caused by vein injection cases of severe local reactions, but must avoid vein around aimlessly drug use.
Recommended dose is 25 mg/m2 fluoride phosphate darla, every 28 days intravenous drug use 5 days in a row, each namesake fizzy 2 mL water for injection, per mL solutions should contain 25 mg fluoride phosphate dara marina.
Extract the corresponding dose (calculated based on patients with body surface area) in the syringe, if is rapid intravenous injection, need to use 10 mL of 0.9% diluted saline.Or, extraction in the syringe dose can also use 100 mL 0.9% after diluted saline drip, drip time should be more than 30 minutes.
The duration of the treatment depends on the effectiveness of treatment and drug tolerance.

In patients with CLL, fluoride phosphate dara marina shall have been used to achieve the best therapeutic effect (complete or partial response, usually need 6 sessions), before stopping.                                                                                                                                                        

 

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