Fludarabine 21679-14-1 C10H12FN5O4
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Fludarabine Basic information |
Product Name: | Fludarabine |
Synonyms: | 2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE |
CAS: | 21679-14-1 |
MF: | C10H12FN5O4 |
MW: | 285.23 |
EINECS: | 244-525-5 |
Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;API |
Mol File: | 21679-14-1.mol |
Fludarabine Chemical Properties |
mp | 265-268°C |
storage temp. | 2-8°C |
solubility | DMF: 20 mg/mL, clear, faintly yellow |
Merck | 13,4152 |
CAS DataBase Reference | 21679-14-1(CAS DataBase Reference) |
Safety Information |
Risk Statements | 23/24/25-36/37/38-39/23/24/25-39 |
Safety Statements | 26-36/37-45 |
WGK Germany | 3 |
RTECS | AU6207000 |
F | 10 |
Hazardous Substances Data | <a title="21679-14-1(Hazardous Substances Data)" dbs+hsdb:@rn+21679-14-1"="" style="margin: 0px auto; padding: 0px; border: 0px;">21679-14-1(Hazardous Substances Data) |
Fludarabine Usage Synthesis |
Chemical Properties | White Solid |
Usage | Used as an antineoplastic |
Usage | A STAT-1 activation inhibita DNA synthesis inhibitor. |
Biological Activity | Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) triggers apoptosis through increasing Bax decreasing Bid, XIAP survivin expression. Displays anticancer activity against hematological malignancies in vivo . |
Fludarabine Preparation Products Raw materials |
Raw materials | Acetic anhydride-->Fluoroboric acid-->Boron trichloride -->2,4,5,6-TETRAAMINOPYRIMIDINE-->2,6-Diaminopurine-->DIACETAMIDE |
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