ITTP Hexasodium Salt

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3, COA/HPLC/HNMR available

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1, About ITPP

myo-Inositol trispyrophosphate (ITPP), a novel membrane-permeant allosteric effector of hemoglobin (Hb), enhances the regulated oxygen release capacity of red blood cells, thus counteracting the effects of hypoxia in diseases such as cancer and cardiovascular ailments. ITPP-induced shifting of the oxygen-hemoglobin equilibrium curve in red blood cells (RBCs) was inhibited by DIDS and NAP-taurine, indicating that band 3 protein, an anion transporter mainly localized on the RBC membrane, allows ITPP entry into RBCs. The maximum intracellular concentration of ITPP, determined by ion chromatography, was 5.5×10(-3) M, whereas a drop in concentration to the limit of detection was observed in NAP-taurine-treated RBCs. The dissociation constant of ITPP binding to RBC ghosts was found to be 1.72×10(-5) M. All data obtained indicate that ITPP uptake is mediated by band 3 protein and is thus highly tissue-selective towards RBCs, a feature of major importance for its potential therapeutic use.

ITPP is an allosteric effector of hemoglobin that increases oxygen availability to tissues. In other words, ITPP doesn't increase oxygen to tissues itself, but rather enhances the ability of red blood cells to do so. As mentioned in the introduction, one fantastic byproduct of this process is increased workout capacity. Another potential benefit that's being studied is ITPP's ability to help reinvigorate damaged hearts through an increased supply of oxygen to the ailing cardiac muscle.

2, Dose

A good dosage guideline for rats is 0.03mg - 0.06mg per day during studies. Regarding humans, I again must stress that ITPP is only intended for non-human research. But anybody who does take the drug should know that those on bodybuilding forums discuss taking between 1g - 2g per week.