aliskiren fumarate

aliskiren fumarate
aliskiren fumarate
aliskiren fumarate
aliskiren fumarate
aliskiren fumarate

aliskiren fumarate

Min.Order / FOB Price:Get Latest Price

1000 Gram

FOB Price: USD 500.0000

  • Min.Order :1000 Gram
  • Purity: 99.5（%）
  • Payment Terms : L/C,T/T,

Keywords

aliskiren fumarate Aliskirenhemifumarate; Aliskiren (heMifuMarate); ALISKIREN FUMARATE; aliskiren hemifumarate; Aliskiren D6 Hemifumarate 173334-58-2

Quick Details

  • Appearance:appearance White powder
  • Application:Widely used in cosmetics, medicine, beauty health food and other industries
  • PackAge:1000 g/aluminum foil bag
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:Dry and ventilated
  • Transportation:shipping

Superiority:

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly  to $2 million, we  have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also  has the advantage of high quality in Africa. in the past two years our products  has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!The quality of our products meet all international standards, the German advanced equipment are imported equipment two laboratories, individual, on scale management concept, our aim is;With the highest quality. The lowest price. The best service to meet the new and old customers around the world, develop together for a better future!

Details:

                                        Keywords

  • Aliskiren hemifumarate
  • Aliskiren
  • Tekturna

Quick Details

  • ProName: Aliskiren hemifumarate in stock
  • CasNo: 173334-58-2
  • Appearance: off-white to white powder
  • Application: for research
  • DeliveryTime: in stock
  • PackAge: aluminum foil bag, carton, customized
  • Port: Shanghai, HongKong
  • ProductionCapacity: 50 Kilogram/Month
  • Purity: 98%
  • Storage: in cool and dry place
  • Transportation: EMS,DHL,FedEx,TNT,HKEMS,HKDHL
  • LimitNum: 10 Gram
  • Moisture Content: 5%
  • Impurity: NA

Superiority

 

1, factory price, top quality guaranteed

2,prompt & fast delivery via DHL, FEDEX, TNT, HKEMS, HKDHL, EMS, etc

3, COA/HPLC/HNMR available

4, reliable provider & satisfactory service

 

Details

Product name

Aliskiren hemifumarate

Chemical name

ALISKIREN FUMARATE;(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate;Aliskiren hemifumarate;Benzeneoctanamide, delta-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-gamma-hydroxy-4-methoxy-3-(3-methoxypropoxy)-alpha,zeta-bis(1-methylethyl)-, (alphas,gammas,deltas,zetas)-, (2E)-2-butenedioate (2:1) (salt);Unii-C8A0p8G029;(αS,γS,δS,zS)-δ-AMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-γ-hydroxy-4-Methoxy-3-(3-Methoxypropoxy)-α,z-bis(1-Methylethyl)benzeneoctanaMide HeMifuMarate;Rasilez HeMifuMarate;Tekturna HeMifuMarate

CAS NO.

173334-58-2

Formula

C30H53N3O6

Color

White powder

Application

for high blood pressure

 

About Aliskiren hemifumarate

Aliskiren (INN) (trade names Tekturna, US; Rasilez, UK and elsewhere) is the first in a class of drugs called direct renin inhibitors. Its current licensed indication is essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.

In December 2011, Novartis halted a clinical trial of the drug after discovering increased incidence of nonfatal stroke, kidney complications, high blood potassium, and low blood pressure in people with diabetes and kidney impairment.

As a result, in April 20, 2012:

While used for high blood pressure, other better studied medications are typically recommended. Prescrire has stated that aliskiren is potentially more harmful than beneficial and thus list it as of 2014 as a drug to avoid.

Renin, the first enzyme in the renin–angiotensin–aldosterone system, plays a role in blood pressure control. It cleaves angiotensinogen to angiotensin I, which is in turn converted by angiotensin-converting enzyme (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure. It directly causes arterial smooth muscle to contract, leading to vasoconstrictionand increased blood pressure. Angiotensin II also stimulates the production of aldosterone from the adrenal cortex, which causes the tubules of the kidneys to increase reabsorption of sodium, with water following, thereby increasing plasma volume, and thus blood pressure. Aliskiren binds to the S3bp binding site of renin, essential for its activity.[7] Binding to this pocket prevents the conversion of angiotensinogen to angiotensin I. Aliskiren is also available as combination therapy with hydrochlorothiazide.                                                                                                                         

 

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