treating brain tumors belustine Api-lomustine
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Formula |
C9H16CIN3O2 |
Molecular weight |
233.70 |
EINECS |
235-859-2 |
CAS RN |
|
CAS Name |
|
Synonyms: |
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; (chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea; (cloro-2-etil)-1-cicloesil-3-nitrosourea; 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure; 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure; belustine; cecenu; ceenu; chloroethylcyclohexylnitrosourea; cinu; cyclohexylchloroethylnitrosourea; icig1109; n-(2-chloroethyl)-n’-cyclohexyl-n-nitroso-ure; nci-c04740; nsc79037; nsc-79037; rb1509; 1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea |
Minimum assay |
≥98% |
Form |
yellow powder |
Solubility |
Soluble in ethanol (47 mg/ml at 25 °C), chloroform, water (<1 mg/ml at 25 °C), DMSO (47 mg/ml at 25 °C), and acetone. |
Application |
Lomustine is clinically used to treat various forms of cancer. |
Usage |
a highly lipid soluble drug, treating brain tumors |
Melting point ca. |
88-90 ºC |
Boiling point ca. |
354.07 °C |
Density g/cm3 (20°C) |
1.31g/cm3 |
Refractive index |
1.57 |
Flash point |
133.2°C |
Stability |
Stable under recommended storage conditions |
Percent Composition |
C 46.25%, H 6.90%, Cl 15.17%, N 17.98%, O 13.69% |
Packaging |
required by customer |
Delivery Time |
overnight (USA/Canada); 3-5 days (worldwide) |
Storage |
Store at 4° C |
Transport information |
by air/sea |
Description
Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine (sc-204671) causing
DNA interstrand cross-linking. The compound is also a documented inhibitor of glutathione reductase, DLD(lipoamide dehydrogenase) and trypanothione reductase. Lomustine is a highly lipid soluble compound thus enabling it to cross the blood
brain barrier and rapidly disperse in tissue. In A2870 cells, Lomustine has been shown to induce p53 expression.
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