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1 Gram |
Negotiable |
1201438-56-3 duvelisib IPI-145
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Description | Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM, highly selective for PI3K δ/γ than other protein kinases. Phase 3. |
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Molecular Weight (MW) | 416.86 |
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Formula |
C22H17ClN6O |
CAS No. | 1201438-56-3 |
Storage | 3 years -20℃powder |
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6 months-80℃in solvent | |
Synonyms | Duvelisib, IPI-145, INK1197 |
Solubility (25°C)* | In vitro | DMSO | 83 mg/mL (199.1 mM) |
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Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
<1 mg/ml means slightly soluble or insoluble. |
Chemical Name | 1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]- |
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