buy Halofuginone high quality Halofuginone Halofuginone factory
Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
Formula |
C16H17BrClN3O3 |
Molecular weight |
414.68 |
EINECS |
|
CAS RN |
55837-20-2 |
CAS Name |
7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one Halofuginone Hydrochloride |
Synonyms |
Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110 rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone Hydrochloride; 7-Bromo-6-chlorofebrifugine Hydrochloride; HAL; |
Minimum assay |
>98% |
Form |
Off-White Solid |
Solubility |
|
Application |
Halofuginone is a halogenated derivative of Febrifugine (F228500). Halofuginone is used as an antiprotozoal. |
Melting point ca. |
247-249°C (dec.) |
Boiling point ca. |
595.8 °C at 760 mmHg |
Density g/cm3 (20°C) |
1.73 g/cm3 |
Refractive index |
|
Flash point |
314.1 °C |
Stability |
|
Packaging |
|
Storage |
Dry, dark and at 0 - 4 C for short term -20 C for long term |
Transport information |
|
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