71675-85-9 71675-85-9 C17H27N3O4S
Amisulpride Basic information |
Product Name: | Amisulpride |
Synonyms: | 4-AMINO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-5-(ETHYLSULFONYL)-2-METHOXYBENZAMIDE;AMISULPRIDE;AMINOSULTOPRIDE;DAN-2163;DENIBAN;SOCIAN;SOLIAN;4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzam |
CAS: | 71675-85-9 |
MF: | C17H27N3O4S |
MW: | 369.48 |
EINECS: | 275-831-7 |
Product Categories: | Active Pharmaceutical Ingredients;Antipsychotic;Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals;Dopamine receptor;DENIBAN |
Mol File: | 71675-85-9.mol |
Amisulpride Chemical Properties |
mp | 124-128 |
storage temp. | 2-8°C |
solubility | DMSO: ≥5 mg/mL |
form | solid |
color | white |
CAS DataBase Reference | 71675-85-9(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | CV2308701 |
MSDS Information |
Provider | Language |
---|---|
Amisulpride | English |
SigmaAldrich | English |
Amisulpride Usage And Synthesis |
Chemical Properties | Off-White Solid |
Usage | Neuroleptic agent, an analogue of sulpiride. Used as an antipsychotic. Dopamine receptor antagonist |
Usage | Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist. |
Biological Activity | Potent, selective dopamine D 2 and D 3 receptor antagonist. K i values are 2.8 and 3.2 nM respectively for human D 2 and D 3 and > 1000 nM for human D 1 , D 4 and D 5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D 2 /D 3 receptors at higher doses. Preferentially interacts with limbic D 2 -like receptors in vivo . Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride. |
Amisulpride Basic information |
Product Name: | Amisulpride |
Synonyms: | 4-AMINO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-5-(ETHYLSULFONYL)-2-METHOXYBENZAMIDE;AMISULPRIDE;AMINOSULTOPRIDE;DAN-2163;DENIBAN;SOCIAN;SOLIAN;4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzam |
CAS: | 71675-85-9 |
MF: | C17H27N3O4S |
MW: | 369.48 |
EINECS: | 275-831-7 |
Product Categories: | Active Pharmaceutical Ingredients;Antipsychotic;Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals;Dopamine receptor;DENIBAN |
Mol File: | 71675-85-9.mol |
Amisulpride Chemical Properties |
mp | 124-128 |
storage temp. | 2-8°C |
solubility | DMSO: ≥5 mg/mL |
form | solid |
color | white |
CAS DataBase Reference | 71675-85-9(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | CV2308701 |
MSDS Information |
Provider | Language |
---|---|
Amisulpride | English |
SigmaAldrich | English |
Amisulpride Usage And Synthesis |
Chemical Properties | Off-White Solid |
Usage | Neuroleptic agent, an analogue of sulpiride. Used as an antipsychotic. Dopamine receptor antagonist |
Usage | Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist. |
Biological Activity | Potent, selective dopamine D 2 and D 3 receptor antagonist. K i values are 2.8 and 3.2 nM respectively for human D 2 and D 3 and > 1000 nM for human D 1 , D 4 and D 5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D 2 /D 3 receptors at higher doses. Preferentially interacts with limbic D 2 -like receptors in vivo . Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride. |
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