High quality Milrin...

High quality Milrinone with best price
High quality Milrinone with best price

High quality Milrinone with best price

Min.Order / FOB Price:Get Latest Price

10 Gram

Negotiable

  • Min.Order :10 Gram
  • Purity: ≥99.8%
  • Payment Terms : L/C,T/T,Other

Keywords

Milrinone purity 99% Milrinone high quality cas 78415-72-2

Quick Details

  • Appearance:Almost white crystalline powder
  • Application:congestive heart failure unresponsive to digitalis, diuretics, or vasodilators
  • PackAge:5kg/barrel or as customers' requirements
  • ProductionCapacity:200|Kilogram|Month
  • Storage:Stored as directed away from heat and light
  • Transportation:by sea/by express

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Details:

Name

Milrinone

Type

Small Molecule

melting point

>300 °C

water solubility

Slightly soluble

Groups

Approved

Description

A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. [PubChem]

Structure
Thumb

Pharmacology

Indication

Indicated for the treatment of congestive heart failure.

Pharmacodynamics

Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

Mechanism of action

Milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.

Absorption

Milrinone is rapidly and almost completely absorbed after oral administration. Bioavailability is 92% (in healthy volunteers).

 

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