High quality Amphotericin B with best price

Product Name:

Amphotericin B

Synonyms:

ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE;AMPHOTERICIN B, STREPTOMYCES NODOSUS;AMPHOTERICIN B, STREPTOMYCES SPECIES

CAS:

1397-89-3

MF:

C47H73NO17

MW:

924.08

Product Categories:

Miscellaneous Natural Products;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;AM to AQAntibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics Antibiotics;Antifungal Antibiotics;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Polyenes;antibiotic

Mol File:

1397-89-3.mol

Chemical Properties

melting point 

>170°C

density 

1.34

storage temp. 

2-8°C

solubility 

sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20℃. Stable at 37℃ for 3 days.

Water Solubility 

<0.1 g/100 mL at 21 ºC

Stability

Stable, but may be light sensitive. Incompatible with strong oxidizing agents

Usage And Synthesis

Chemical Properties

Crystalline Yellow Solid

Usage

Polypeptide antibiotic active against gram positive bacteria. Antifungal.

Usage

Amphotericin B is heptaene polyene antifungal originally discovered as a metabolite of Streptomyces nodosus in 1956. Amphotericin B acts by binding sterols in the cell membrane leading to the formation of transmembrane channels and subsequent ion leakage. Amphotericin B is poorly water soluble so has been developed for therapeutic use as a complex with desoxylate or in liposomes to improve bioavailability. Amphotericin B is widely used as a research reagent in diverse applications with over 15,000 literature citations