(2R,3R,4S,5S)-5-(4-...

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol -

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol -

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 98% min
  • Payment Terms : L/C,T/T,

Keywords

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol 123318-82-1

Quick Details

  • Appearance:White to offwhite crystalline powder
  • Application:Intermediate
  • PackAge:Fluorinated botte, drums or woven bags, drum, kraft paper bag or customer's request
  • ProductionCapacity:100|Metric Ton|Year
  • Storage:N/A
  • Transportation:---

Superiority:

(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
 
Chemical Name : (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
 
CAS: 123318-82-1
 
Molecular formula:
 C10H11ClFN8O3
 
Molecular weight: 303.68
 
 
 
Useing:

Be used to manufacture Antitumour medicine

 

Details:

Clofarabine Basic information

Product Name: Clofarabine
Synonyms: 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE;5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;CLOFARABINE;CAFDA;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine;Clolar
CAS: 123318-82-1
MF: C10H11ClFN5O3
MW: 303.68
EINECS:  
Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Bases & Related Reagents;Nucleotides;Pharmaceutical intermediate;CLOLAR;Antineoplastic;Anti-cancer&immunity
Mol File: 123318-82-1.mol
Clofarabine Structure
 
Clofarabine Chemical Properties
mp  228-2310C
storage temp.  Desiccate at +4°C
CAS DataBase Reference 123318-82-1(CAS DataBase Reference)
 
Safety Information
Hazard Codes  T
Risk Statements  25
Safety Statements  45
MSDS Information
 
 
Clofarabine Usage And Synthesis
Chemical Properties White Solid
Usage ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic
Biological Activity Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

 

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